Endocrine Abstracts

Background: Cardiovascular (CVS) risk factors could be present in patients with mild adrenal autonomous cortisol secretion (MACS), which could account for up to 50% of patients with adrenal adenomas. However, the most frequent CVS risk factors in MACS have not been established.Objective: The aim of the present study was to analyse the difference in CVS risk factors in patients with MACS in comparison to those with non-functioning adrenal tumour (NFAT).</...

Differentiated thyroid cancer (DTC) is the most common malignant neoplasm arising from the thyroid parenchymal cells. DTC risk stratification is a multi-stage process based on investigated histopathological features and ultrasound test outcomes combined with biochemical test results. Thus, searching for novel diagnostic indicators useful in cancer risk stratification are still needed. Recent studies revealed that oxidative and epigenetic alterations in DTC represent the signat...

Acromegaly is characterized by two-fold higher mortality than in the general population. The leading causes of morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVD). Many population-based studies suggest a role of genetic background in CVD and associated metabolic disturbances. In 2007, FTO (fat mass and obesity associated) gene polymorphisms were discovered. According to a few studies, the polymorphisms of FTO gene are associated with ...

Objectives: In the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors thyroid tumors are divided into several new categories that allow for a clearer understanding of the cell of origin, pathologic features, molecular classification, and biological behavior. According to this classification there are some borderline nodules -the group of low-risk follicular cell-derived neoplasms - such as noninvasive follicular thyroid neoplasm with papillary-like nu...

Hashimoto disease, a chronic autoimmune lymphocytic thyroiditis, is the most common cause of hypothyroidism with a prevalence of 10–12% in the general population. Literature data suggests that persistently high levels of oxidative are considered as relevant risk factor in the occurrence and development of autoimmune diseases, including Hashimoto. The DNA and RNA are particularly valuable to the oxidative damage, and guanine is the most prone base to oxidation. Thus, the D...

Objectives: The excessive production of pro-inflammatory cytokines has been previously reported in the severe form of COVID-19. The cytokine storm is responsible for the induction of an inflammatory endothelial cell phenotype which is associated with the shedding of adhesion molecules. VCAM-1 is an endothelial adhesion protein that belongs to the immunoglobulin superfamily. Pro-inflammatory cytokines lead to the induction of VCAM-1 in the endothelium of blood vessels which is ...

Introduction: Graves’ disease during pregnancy may cause maternal or neonatal complications, including arrhythmia, thyroid storm, congenital anomalies and neonatal thyroid dysfunction (TD). The optimal timing and frequency of TRAb measurement in pregnant women with a history of TD, and whether fetal monitoring could be limited to those with a strongly positive TRAb, is unclear.Methods: Retrospective case note review of women with elevated TRAb (>1 i...

Introduction: Patients with connective tissue diseases are susceptible to the occurrence of side-effects of long term treatment with low-dose glucocorticoids as these medications often cannot be withdrawn due to exacerbation of the underlying disease. The new-onset of glucose metabolism impairment is not considered common in patients treated with low-dose glucocorticoids and the risk factors are thought to be the same as in general population: increasing age, obesity or family...

Thyroid carcinoma showing thymus-like differentiation (CASTLE) is an extremely rare thyroid neoplasm. This type of tumour may arise from branchial pouch remnants or ectopic thymus and is considered as independent clinicopathological entity of thyroid neoplasms. There have been only about 100 cases described in the literature, so far. Here, we have retrospectively analyzed the data from histopathology and clinics of a 70 year old female patient with thyroid CASTLE who underwent...

Introduction: According to a limited number of specialized hospital beds for radioiodine therapy in some countries, fractionated dose of radioiodine may be considered as the ablation therapy of differentiated thyroid cancer (DTC). Aim of the study was to compare the late effects of ablation therapy with single and fractionated dose of radioiodine in patients with DTC.Patients and metods: Patients with DTC treated with one (131)I dose of 2.2 GBq or fracti...